Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis

Table 2

Causes for abnormal prothrombin time and prolonged activated partial thromboplastin time.

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Common medical states

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Liver diseases

Disseminated intravascular coagulation

Vitamin K deficiency

Extensive blood product transfusion

Anticoagulant therapy

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Factor deficiencies

Deficiency in single or multiple factors X, V, II

Antibodies against these factors

Pan-inhibitors (e.g., lupus anticoagulant, immunoglobulin)

Dysfibrinogenemia, hypofibrinogenemia

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Presence of an inhibitor

Circulating immunoglobulin

Lupus anticoagulant

Heparin contamination

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Preanalytical factors

Prolonged sample storage

Clotted sample

Heparin contamination

Relative excess of citrate/plasma (polycythemia, insufficient tube filling)

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