Gilteritinib as Bridging and Posttransplant Maintenance for Relapsed Acute Myeloid Leukemia with FLT3-ITD Mutation Accompanied by Extramedullary Disease in Elderly

Figure 1

Macroscopic and histological findings of skin lesions with infiltration of leukemic cells at relapse (hematoxylin-eosin staining and immunostaining) and macroscopic findings on day 14 of cord blood transplantation (a). Scattered eruptive skin lesions are observed in the abdomen (A1). Pathologically, there is diffuse proliferation of leukemic cells, with positivity for c-kit and HLA-DR. Skin lesions disappeared after the conditioning regimen, and a rash due to acute graft-versus-host disease developed on day 14 of cord blood transplantation (A2). Macroscopic findings of drooping of the right eyelid with extroversion of the eye due to right oculomotor palsy (b) at relapse (B1) and at one month after cord blood transplantation (B2).

(a)

(b)