| | | Yang et al. [6] | Sripanidkulchai and Lumbiganon [7] | Rajagopala et al. [8] | Krishnamurthy et al. [9] | Kodan et al. [10] | Barman et al. [11] | Jevtic et al. [12] | Our patient (2021) |
| | Age (years) | 61 | 8.6 | 53 | 4 | 24 | 40 | 13 | 74 |
| | Sex | Female | Male | Female | Male | Male | Male | Female | Male |
| | Country | Taiwan | Thailand | India | India | India | India | Serbia | Sri Lanka |
| | Comorbidities | Type 2 DM for 4 years, psoriasis vulgaris for 10 years | NA | NA | None | NA | None | None | Type 2 DM, hypertension |
| | Presentation | 4-day history of abdominal pain, malaise, diarrhoea, and intermittent fever | Fever >37.8°C for more than 6 days | Fever, delirium, purpura for 10 days | High-grade fever for 7 days | Fever and oliguria | High-grade fever for 10 days, yellowish discolouration of the eyes and urine for 4 days, recurrent nasal bleeding for 2 days | A 20-day history of fever, swelling, and neck pain following a rash | High-grade fever for 7 days |
| | Diagnostic criteria for sHLH | Fever: 39°C, splenomegaly, WBC: 1900, Hb: 10.1, TG-: 414, S. ferritin: 9152, BM biopsy: HS | Fever, leukopenia, thrombocytopenia | Fever, organomegaly, TG: 366, S. ferritin: 16,192, BM aspiration: HS | Fever, organomegaly, TG: 658, S. ferritin: 1329, BM biopsy: HS | Fever, organomegaly, cytopaenia, S. ferritin: 6360, BM biopsy: HS, TG: NA | Fever >39°C, organomegaly, WBC: 1500, Hb: 6.5, TGL 525, S. ferritin: 1400, BM biopsy: HS | Fever, organomegaly, Hb: 9.4, Plt: 63,000, S. ferritin: 1500, BM biopsy: HS, soluble interleukin-2R alpha | Fever >38.5 C, Hb: 7.8 g/dl, Plt <40,000, organomegaly, S. ferritin: 60,685, TG: 358, BM biopsy: HS |
| | Management | Ceftriaxone, metronidazole, day 07: oral doxycycline, intermittent haemodialysis | NA | Steroids, antimicrobials, mechanical ventilation, vasopressors | Ceftriaxone and prednisolone | Corticosteroids | Ceftriaxone, doxycycline, methylprednisolone | Meropenem and cefuroxime, IVIG, corticosteroids, haemodialysis | Ceftriaxone, methylprednisolone/dexamethasone, etoposide, intermittent haemodialysis, lung-protective ventilation |
| | Complications | AKI deteriorating liver functions, generalized seizures, coma | Ascites, pericardial effusion, cardiogenic shock | AKI, ARDS, fulminant hepatic failure | NA | NA | Refractory hypotension, pancytopaenia, progressive hypoxemia requiring mechanical ventilation | AKI | AKI, severe ARDS, pulmonary haemorrhages |
| | Number of hospital days | 12 | 21 | 7 | 3 weeks | NA | 12 | 35 | 08 |
| | Outcome | Death | Responded to therapy | Death following CRBSI | Responded well to the treatment; haematological and biochemical derangements normalized at one year | Responded to therapy | Death following cardiac arrest | Full recovery | Death following cardiac arrest |
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