| | Study | Country | Number of patients | Median age | Comorbidities | Clinical presentation | Radiological findings | Site of TB | COVID treatment | TB treatment | Mortality |
| | Tadolini et al. [28] | Multicenter | 49 | 49 | 8 COPD/asthma, 8 diabetes, 6 HIV, 5 kidney disease, 7 liver disease, 10 alcoholism, 20 smoking, 4 drug abuse | 32 fever, 27 cough, 17 dyspnea | 21 bilateral GGO, 23 cavitation, 25 infiltrates | 36 pulmonary, 1 extrapulmonary, 12 both | 22 HCQ, 12 antiviral therapy, 7 AZT, 1 other | NM | 6 deaths | | Gupta et al. [12] | India | 22 | 44 | 3 diabetes, 4 hypertension, 2 seizure disorder, 1 hypothyroidism | 22 fever, 11 cough, 7 dyspnea, 1 weight loss, 1 headache | 14 bilateral infiltrates typical of COVID, 9 pulmonary fibrosis, 3 cavitations, 6 infiltrates/consolidation, 2 pleural effusion | 17 pulmonary, 4 extrapulmonary; 1 disseminated | NM | 21 (RIF, INH, PYR, ETB), 1 MDR therapy | 6 deaths | | Stochino et al. [5] | Italy | 20 | 40 | 1 COPD, 4 diabetes, 1 psoriasis, 1 hypertension, 1 sickle cell disease | 12 fever, 9 cough, 3 dyspnea, 3 chest pain, 2 headache, 1 conjunctivitis, 3 asymptomatic | 1 GGO, 3 interstitial syndrome, 8 cavitations, 14 nodules, 1 pleural effusion, 1 calcification, 2 miliary | 16 pulmonary, 1 extrapulmonary, 2 both, 1 disseminated | 20 HCQ | 14 (RIF, INH, PYR, ETB), 2 MDR therapy, 4 tailored therapy | 1 death | | Gül et al. [22] | Turkey | 16 | 40.68 | 2 smoking, 2 asthma, 2 cardiac disease, 2 diabetes | 3 fever, 7 cough, 3 dyspnea, 2 headache, 4 anorexia, 1 hemoptysis, 1 skin rash, 4 asymptomatic | 9 GGO, 6 infiltration, 4 cavitations, 1 nodules, 1 pleural effusion | 9 pulmonary, 5 extrapulmonary, 1 both | 10 HCQ, 8 FAV | 13 (RIF, INH, PYR, ETB), 1 (RIF, INH, PYR, STR), 1 (RIF, INH, STR, ETB) | 1 death | | He et al. [16] | China | 3 | 56.3 | 2 smoking | 3 fever, 3 cough, 1 chest pain, 2 dyspnea | 3 GGO, 1 cavitation | 3 pulmonary | 3 LOP/RIT, Arbidol | 1 (RIF, INH, PYR, ETB) | 0 | | Liu et al. [17] | China | 3 | 40 | 1 MDR-TB, 1 Aspergillus infection | 3 fever, 2 dyspnea, 2 cough, 1 myalgia, 1 sore throat, 1 chest pain, 2 respiratory distress, 2 hemoptysis | 3 GGO | 3 pulmonary | 1 AZT, 3 Arbidol, 3 MOX, 2 LNZ | 1 (ETB/PYR/AMK/LEV), 1 CS, 1 CFZ, 1 LNZ | 0 | | Yao et al. [18] | China | 3 | 50.3 | 2 smoking, 1 diabetes | 3 fever, 3 cough, 3 weight loss, 1 night sweat | 3 GGO, 2 pleural effusion | 3 pulmonary | 2 LOP/RIT, 1 UMF HCL, 2 IFN-α | 2 RIF, INH, PYR, ETB | 1 death | | Cao et al. [19] | China | 1 | 47 | Asthma | Unwellness, poor appetite | Cavern calcification | Pulmonary | LOP/RIT | RIF, INH, PYR, ETB | 0 | | Tham et al. [10] | Singapore | 4 | 31.75 | NM | 4 fever, 4 cough, 1 dyspnea, 1 weight loss | 1 GGO, 1 cavitation, 2 pleural effusion,3 consolidations | 4 pulmonary | NM | 4 RIF, INH, PYR, ETB | 0 | | Al Lawat et al. [29] | Oman | 2 | 49 | 1 smoking, 1 diabetes, 1 hypertension | 2 fever, 2 cough,1 dyspnea, 1 chest pain, 1 headache, 1 weight loss | 1 cavitations, 2 nodules | 2 pulmonary | 2 CTX, CLR, and OSE, 2 HCQ, 1 LOP/RIT | 2 RIF, INH, PYR, ETB | 0 | | Gadelha Farias et al. [20] | Brazil | 2 | 41 | 1 HIV, 1 hepatitis B | 1 fever, 1 cough, 2 respiratory distress, 1 headache, 1 hemoptysis | 2 GGO, 1 cavitation | 2 pulmonary | 2 HCQ, 2 AZT, 2 CTX | 2 RIF, INH, PYR, ETB | 0 | | Yousaf et al. [30] | Qatar | 6 | 35.5 | 1 diabetes mellitus | 3 fever, 5 cough, 2 myalgia, 2 headache, 5 weight loss | 6 infiltrations, 6 cavitation, 1 pleural effusion | 6 pulmonary | 6 (HCQ, AZT, CTX) | 6 (RIF, INH, PYR, ETB) | NM | | Shabrawishi et al. [24] | Saudi Arabia | 7 | 34.8 | 1 HIV | 7 fever, 6 cough, 2 hemoptysis, 4 night sweats, 6 anorexia, 6 weight loss | 1 GGO, 7 consolidation, 3 cavitations, 2 nodules, 1 pleural effusion, 1 pneumothorax | 6 pulmonary, 1 both | 4 (AZT, CTX), 1 HCQ, 1 (RIB, INH, LOP/RIT) | 7 RIF, INH, PYR, ETB | 1 death | | Khayat et al. [25] | Saudi Arabia | 1 | 40 | None | Fever, cough, body aches, chest pain, anorexia | Consolidation | Pulmonary | NM | RIF, INH, PYR, ETB | 0 | | Baskara et al. [31] | Indonesia | 1 | 42 | Diabetes | Dizziness, headache, cough, abdominal pain, night sweats | GGO | Pulmonary | AZT, CTX, CTZ, HCQ, OSE | RIF, INH, PYR, ETB | 0 | | Vilbrun et al. [32] | Haiti | 1 | 26 | MDR-TB | Fever, cough, dyspnea, weight loss | Cavitation Consolidation | Pulmonary | NM | BDQ, LEV, LNZ, CFZ PYR | 0 | | Luciani et al. [6] | Italy | 1 | 32 | BCG vaccination | Fever, myalgia | Consolidation pleural effusion | | LOP/RIT, HCQ, LNZ, CLR, TZP | RIF, INH, PYR, ETB | 0 | | Musso et al. [7] | Italy | 1 | 45 | Immunosuppression, alcoholism | Fever, cough, fatigue, weight loss, respiratory failure. | GGO, cavitation, hydropneumothorax, atelectasis | Pulmonary | HCQ, corticosteroids | RIF, INH, ETB, PYR, AMK, MOX | Death | | Lovino et al. [8] | Italy | 1 | 45 | None | Fever, productive cough, hemoptysis, myalgia | GGO, excavated consolidation | Pulmonary | NM | NM | 0 | | Rivas et al. [33] | Panama | 2 | 41 | 2 HIV | 2 fever, 1 cough, 2 dyspnea, 1 weight loss | 2 infiltrations | Pulmonary | 2 AZT, 2 HCQ, 1 CTX, 1 LEV, 1 antiviral therapy | 2 RIF, INH, PYR, ETB | 0 | | Pozdnyakov et al. [34] | Canada | 1 | 64 | Diabetes, hypertension, and dyslipidemia | Dyspnea, respiratory distress syndrome | GGO, interstitial syndrome | Pulmonary | CTX | RIF, INH, PYR, ETB | 1 death | | Faqihi et al. [26] | Saudi Arabia | 1 | 60 | Diabetes, hypertension | Fever, cough, chest pain, respiratory distress, | GGO | Pulmonary | LOP/RIT, RIB, DEX | RIF, INH, PYR, ETB | 0 | | Starshinova et al. [35] | Russia | 1 | 59 | Heart disease, COPD, emphysema, tuberculosis | Fever, rhinitis, cough, shortness of breath | GGO, infiltration, consolidation, pneumothorax, emphysema | Pulmonary | CTX, LEV, AZT | RIF, INH, PYR, ETB | 0 | | Orozco et al. [27] | Mexico | 1 | 51 | Diabetes | Anosmia, dysgeusia, cough, dyspnea | GGO cavitation | Pulmonary | Oxygenotherapy | RIF, INH, PYR, ETB | 0 | | Marwah et al. [13] | India | 1 | 34 | MDR tuberculosis, chronic hepatitis B | Productive cough, dyspnea, weight loss, fever, respiratory failure | Cavitation nodules | Pulmonary | Corticosteroids, oxygenotherapy | RIF, INH, ETB, PYR, BDQ | 0 | | PatiL and Gondhali [14] | India | 1 | 75 | Ex-smoker | Fever, productive cough, dyspnea, anorexia, weight loss, hemoptysis. | GGO, cavitation infiltrates | Pulmonary | Remdesivir, corticosteroids, anticoagulation | RIF, INH, ETB, PYR | 0 | | Yadav and Rawal [15] | India | 1 | 43 | None | Fever productive cough, chest pain, dyspnea, night sweats, respiratory distress. | Bilateral consolidation | Pulmonary | NM | RIF, INH, ETB, PYR | 0 | | Yadav et al. [36] | India | 1 | 26 | None | Fever productive cough, chest pain, dyspnea, hemoptysis, weight loss, anorexia. | Consolidation | Pulmonary | NM | INH, ETB, PYR, kanamycin, MOX, CFZ, ethionamide | 0 | | Jacob et al. [37] | India | 1 | 20 | Multiple sclerosis | Fever productive cough, weight loss | Opacity | Pulmonary | Corticosteroids, oxygenotherapy, antibiotics | RIF, INH, ETB, PYR | 0 | | Ata et al. [38] | India | 1 | 28 | Glioma | Dizziness, headache, vomiting | GGO nodules | Pulmonary with CNS involvement | HCQ, AZT | RIF, INH, PYR, ETB, pyridoxine | 0 | | Goel Sharma et al. [39] | India | 1 | 53 | Diabetes chronic kidney disease | Fever, cough, dyspnea, hemoptysis, respiratory distress | GGO, consolidation, fibrosis | Pulmonary | Ampicillin, AZT, HCQ | RIF, INH, PYR, ETB | 0 | | Singh et al. [40] | India | 1 | 76 | Hypertension | Fever, respiratory distress, cough, anorexia, weight loss | GGO Consolidation, pleural effusion | Pulmonary | AZT, HCQ, corticosteroids | RIF, INH, PYR, ETB | 0 | | Sahara and Yokota [41] | Japan | 1 | 59 | None | Fever, productive cough, hemoptysis, anorexia, taste and smell disorders | GGO, tree-in-bud pattern | Pulmonary | NM | RIF, INH, ETB, PYR | 0 | | Ortiz-Martínez et al. [42] | Colombia | 1 | 34 | HIV drug use, anxiety disorder | Fever, dyspnea, headache, cachexia, respiratory distress | GGO, miliary, pleural effusion | Pulmonary | SAM, DOX, corticosteroids, oxygenotherapy | NM | Death | | Aissaoui et al. [43] | French Guiana | 1 | 30 | NM | Fever, cough, dyspnea, genera status alteration, weight loss, night sweats | Consolidation, tree-in-bud pattern | Pulmonary | CTX, DOX | RIF, INH, ETB, PYR | 0 | | Bouaré et al. [44] | Morocco | 1 | 32 | HIV | Fever cough, headache, myalgia. | Miliary | Pulmonary | HCQ, AZT | RIF, INH, ETB, PYR | 0 | | Cutler et al. [45] | USA | 1 | 61 | Parkinson | Fever, cough, hemoptysis | Pleural effusion, atelectasis | Pulmonary | HCQ, oxygenotherapy | RIF, INH, ETB, PYR | 0 | | Freij et al. [46] | USA | 1 | 5 | Group A streptococcal pharyngitis | Fever, headache | Clear | Extrapulmonary | AMX, HCQ, AZT, corticosteroids, remdesivir | None | Death | | Butt et al. [47] | UK | 1 | 42 | None | Dyspnea fever, dry cough, fatigue | GGO, Pleural effusion, Consolidation | Pulmonary | DEX, remdesivir | RIF, INH, ETB, PYR | 0 | | Çinar et al. [23] | Turkey | 1 | 55 | Myelodysplastic disease, kidney disease, Klebsiella pneumoniae infection | Fever, cough, dyspnea | GGO | Disseminated | Plasma therapy, FAV, TCZ, meropenem | RIF, INH, PYR, ETB | 0 | | Tolossa et al. [48] | Ethiopia | 1 | 55 | HIV | Fever productive cough, headache, chest pain, dyspnea, night sweats, weight loss, anorexia, fatigue, hemoptysis | Patchy opacities | Pulmonary | Cefepime, corticosteroids | RIF, INH, PYR, ETB | 0 | | Bongomin et al. [49] | Uganda | 1 | 37 | HIV, cryptococcal meningitis | Fever productive cough, dyspnea, night sweats, weight loss, anosmia, headache, myalgia, episodes of loss of consciousness. | GGO, miliary | Disseminated | TZP, corticosteroids, oxygenation | None | Death | | Wong et al. [11] | Singapore | 1 | 47 | None | Fever, chest pain, productive cough, dyspnea. | Opacities cardiomegaly | Extrapulmonary (pericardiac) | Remdesivir, oxygenotherapy | RIF, INH, PYR, ETB | 0 | | Kozinska and Augustynowicz-Kopeć [50] | Poland | 2 | 67.5 | 1 smoking, 1 HIV, 1 atrial fibrillation,1 renal insufficiency, 2 treated pulmonary TB, treated urogenital TB | 1 (cough, fever, dyspnea, sore throat.), 1 no data | 1 (atelectasis pleural effusion), 1 no data | 1 pulmonary, 1 disseminated | No data | 1 (RIF, INH, PYR, ETB), 1 no data | 1 death | | Gerstein et al. [51] | USA | 1 | 49 | Alcoholism cirrhosis | Fever, dry cough, orthopnea, abdominal pain | Pleural effusion, opacities | Disseminated | HCQ, plasma infusion | RIF, INH, ETB, LEV | 0 | | Mulale et al. [52] | Botswana | 1 | 3 months | None | Fever, cough, respiratory distress, failure to thrive | Infiltrates, opacities, consolidations | Disseminated | Ampicillin, gentamicin, oxygenotherapy | RIF, INH, PYR, ETB | Death | | Essajee et al. [53] | South Africa | 1 | 2 y 7 months | Cerebral venous thrombosis | Lethargy, hemiplegia, respiratory distress | Miliary | Disseminated | Corticosteroids, oxygenotherapy, antibiotics | RIF, INH, PYR, ethionamide, corticosteroids | 0 | | Brandi et al. [9] | Italy | 1 | 78 | Bladder cancer, BCG intravesical instillation, diabetes, COPD, abdominal aortic aneurysm | Fever, cough, dysuria, dyspnea, respiratory distress | GGO, miliary | Disseminated | NM | RIF, INH, ETB | Death | | Osejo-Betancourt et al. [54] | Colombia | 1 | 71 | Smoking | Fever, dry cough, dyspnea, malaise, anosmia, dysgeusia | Bilateral alveolar opacities, cavitation, consolidation, nodules | Pulmonary | DEX, SAM, oxygenotherapy | RIF, INH, PYR, ETB | 0 | | Pinheiro et al. [21] | Brazil | 1 | 68 | Diabetes, hypertension, chronic liver disease | Fever dyspnea, cough, | GGO, opacities, consolidations | Pulmonary | NM | NM | NM | | Orozco et al. [27] | Mexico | 1 | 51 | Diabetes | Anosmia, dysgeusia, nocturnal diaphoresis, cough, respiratory distress. | GGO, cavitation, nodules | Pulmonary | Oxygenotherapy | RIF, INH, PYR, ETB | 0 | | Gbenga et al. [55] | Nigeria | 2 | 31.5 | None | 2 fever, 2 cough, 2 weight loss, 1 respiratory distress, 1 sore throat. | 1 reticulonodular infiltrates, 1 opacity | Pulmonary | 2 AZT, 2 LOP/RIT, 2 (Vit C, zinc sulfate, prednisone) | 2 RIF, 2 INH,2 PYR, 2 ETB | 0 |
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