Haematologic and Urologic Manifestations of Cryptococcus neoformans

Table 1

Summary of investigations.

	Microscopy	Fungal culture	Cryptococcal lateral flow antigen assay	Cryptococcal nucleic acid amplification test
Blood	Case 1: budding yeast seen; Case 2: budding yeast seen	Case 1: culture positive for C. neoformans complex; Case 2: culture positive for C. neoformans complex	Case 1: detected, peak titre 1 : 16; Case 2: detected, peak titre >1 : 1024	Case 1: not performed; Case 2: not performed
Urine	Case 1: budding yeast seen; Case 2: negative	Case 1: culture positive for C. neoformans complex; Case 2: culture negative	Case 1: not performed; Case 2: not performed	Case 1: not performed; Case 2: not performed
CSF	Case 1: negative; Case 2: India ink stain positive, moderate budding yeast seen	Case 1: culture negative; Case 2: positive for C. neoformans complex	Case 1: negative; Case 2: positive, peak titre >1 : 1024	Case 1: not detected; Case 2: detected
Bone marrow	Case 1: negative; Case 2: positive (Grocott stain)	Case 1: culture negative; Case 2: culture positive for C. neoformans complex	Case 1: not performed; Case 2: not performed	Case 1: not performed; Case 2: not performed