Rhizomucor and Scedosporium Infection Post Hematopoietic Stem-Cell Transplant
Figure 3
Ethmoiditis due to Scedosporium apiospermum. (a) Mucosa lined by respiratory type epithelium with intense inflammatory reaction (hematoxylin and eosin [H&E] staining, magnification ×100); (b) higher magnification (×400) of (a) it can be identified numerous epithelioid granulomas and multinucleated giant cells; (c) partially destroyed bone tissue and numerous fungal hyphae (H&E staining, magnification ×100); (d) morphologically the fungal hyphae resemble Aspergillus spp. (H&E, magnification ×400); (e) bone tissue destruction by fungal hyphae (PAS staining, magnification ×100); (f) the main host response is a mixed neutrophilic and monocytic infiltrate (PAS staining, magnification ×400).