Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

Table 2

Summary of cases of patients with SLCT and with RMS elements.

Case number/case report author	Age	Stage	Initial treatment	Outcome
1/Plastini	32	Ia	Local resection	Recurrence at 5 months, then radical hysterectomy followed by 2 cycles of doxorubicin/ifosfamide/vincristine, and then 4 cycles of etoposide/ifosfamide. 10 months later recurrence leads to 3 cycles of BEP. Bleomycin was held for cycles 4 through 8. At 3 and 11 months later it had recurrence treated with radiation. Recurrence at 5 months leads to hospice
2/Plastini	30	Ia	Local resection	Lost to follow-up for 13 months and then repeat surgery for recurrence. Two months later, given 6 cycles of total of doxorubicin/ifosfamide/vincristine. Repeat recurrence, given 6 cycles of irinotecan/temozolomide/vincristine. Further progression with small bowel obstruction requiring debulking surgery and ultimately hospice care
3/Plastini	23	Ia	Debulking surgery, USO, and appendectomy	Sp 6 cycles of doxorubicin, ifosfamide, and vincristine and is currently NED (10 months)
4/Grove	29	Ic	USO	NED at 4 years
5/Guerard	16	Ic	Unilateral oophorectomy	Abdominal deposits at 6–10 months
6/Kostopoulou	22	Ia	Unilateral oophorectomy	NED at 10 months
7/Rekhi	17	Ia	TAH-BSO, omentectomy	Omental deposits at 1 year, lost to follow-up
8/Chougule	23	NS	USO	Unknown
9/Zaloudek	16	Ia	USO	Treated with thiotepa and 5-fluorouracil after recurrence at 1.4 years. Died 4 months later with peritoneal metastases on autopsy
10/Papler	70	Ia	Hysterectomy with LSO, appendectomy, omentectomy, and pelvic and para-aortic lymphadenectomy	Recurrence at 7 months with palliative treatment for symptoms
11/Prat	32	Ia	TAH-RSO	Died 5 months later, found to have peritoneal recurrence
12/Prat	22	Unknown	Unknown	Unknown
13/Prat	17	Ia	LSO	Recurrence in R ovary and pelvis at 6 months leads to TAH-RSO and omentectomy. Second recurrence 3 months later treated with melphalan and resection. Died at 1 year
14/Prat	20	IIa	TAH-BSO	At 5 months found to have peritoneal recurrence treated with resection, doxorubicin, and radiation (7600r.) Died at 10 months
15/Prat	36	IIb	RSO	At 5 months found to have peritoneal recurrence and bowel obstruction. Died at 6 months
16/Prat	16	Ia	RSO	Recurrence in left ovary at 6 months treated with TAH-LSO. Second recurrence at 5 years found in peritoneum treated with resection and questionable chemotherapy. Died at 7 years
17/Prat	20	IIb	RSO, intraabdominal BCG, VAC, and doxorubicin	At 4 months recurrence in cul-de-sac and left ovary treated with TAH-LSO and resection. Second recurrence at 7 months in rectovaginal septum treated with radiation (4600r.) Died at 18 months
18/Prat	48	Ia	TAH-LSO	Not documented
19/Prat	23	Ia	RSO	Recurrence in pelvis and peritoneum at years 1 and 2, respectively, treated with unspecified chemotherapy. Patient alive with tumor at 2-year follow-up