Diffuse Gastric Ganglioneuromatosis: Novel Presentation of <i>PTEN</i> Hamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a Novel <i>PTEN</i> Gene Mutation

<div>(a) Esophageal squamous mucosa with upper keratinocytes showing “cleared out” cytoplasms, characteristic for glycogenic acanthosis, and a rare eosinophil, consistent with minimal reflux (H&amp;E 20x). (b) PAS without diastase digestion showing granular magenta positivity in keratinocytic cytoplasms of the upper half of the squamous mucosa, typical for glycogenic acanthosis (PAS 20X). (c) PAS with diastase digestion showing absence of the positive magenta granularity in the keratinocytic cytoplasms of the upper half of the squamous mucosa, confirming glycogenic acanthosis (PASD 20x).</div>

Case Reports in Medicine

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Figure 1: Diffuse Gastric Ganglioneuromatosis: Novel Presentation of <i>PTEN</i> Hamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a Novel <i>PTEN</i> Gene Mutation 

Figure 1 | Diffuse Gastric Ganglioneuromatosis: Novel Presentation of PTEN Hamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a Novel PTEN Gene Mutation 