Examination of Molecular Effects of <i>MYLK</i> Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction

<div>MYLK electrostatic mapping for full length and truncation. (a) Full-length model for the entire MYLK structure with electrostatics calculated using Poisson–Boltzmann (PB) calculation overlaid onto the structure. The kinase domain is boxed to emphasize its position in the protein. (b) Variant p.S1218del MYLK model is given with electrostatics overlaid indicating changes in charge. Here, the deletion of the crucial kinase domain is shown. (c) As indicated in the boxed region, the secondary structure for the protein kinase domain region is shown (rotated 90° to emphasize the catalytic region (on top).</div>

Case Reports in Medicine

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Figure 3: Examination of Molecular Effects of <i>MYLK</i> Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction 

Figure 3 | Examination of Molecular Effects of MYLK Deletion in a Patient with Extensive Aortic, Carotid, and Abdominal Dissections That Underlie the Genetic Dysfunction 