Vaccine-Associated Disease Enhancement (VADE): Considerations in Postvaccination COVID-19

Figure 3

A schematic timeline of events showing SARS-CoV-2 exposure, PCR status, vaccine administration, the development of symptoms, inflammation, and the possibility of vaccine-associated disease enhancement (VADE) and enhanced respiratory disease (ERD). Upon the exposure to SARS-CoV-2, inflammation (red line) can occur until the symptom onset. During this period, the inflammation response can be amplified by the presence of VADE or ERD (pink arrow) when the patient had already been exposed to vaccinations (orange arrow).