Atypical Antiglomerular Basement Membrane Disease in a Pediatric Patient Successfully Treated with Rituximab

Figure 1

Renal biopsy findings. (a) One glomerulus showing segmental endocapillary hypercellularity, karyorrhectic nuclear debris, and a small cellular crescent (periodic acid-Schiff; original magnification: 400x). (b) Nearly, all of the remaining glomeruli demonstrate no significant abnormalities (periodic acid-Schiff; original magnification: 200x). (c) Immunofluorescence for IgG reveals diffuse, global, linear staining within the glomerular basement membrane (original magnification: 200x). (d) Widespread, subtle subendothelial widening is noted on electron microscopy, without the presence of any immune deposits (original magnification: 4800x).

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