High-Grade Glioma of the Ventrolateral Medulla in an Adult: Case Presentation and Discussion of Surgical Considerations

Figure 3

Histopathology of medullary tumor. (a) Multiple small fragments of the biopsy include one with significant necrosis, one with relatively high cell density, and one with considerable hemorrhage. H&E, original magnification 100x. (b) At high magnification, this portion of the biopsy shows tumor with moderate cell density bordering necrotic tumor. H&E, original magnification 400x. (c) Many of the tumor cells have cytoplasmic GFAP immunoreactivity, establishing their astrocytomatous phenotype. Original magnification 600x. (d) A Ki67 immunostain shows a proliferative index of up to about 25%, consistent with the diagnosis of a high-grade glioma. Original magnification 200x.

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