Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination

Figure 2

(a) Hematoxylin and eosin analysis shows angular and rounded atrophic fibers, diffuse inflammatory reaction, foci of fiber necrosis, and phagocytosis of necrotic fibers. (b and c) Transmission electron microscopy analysis reveals variation in fiber caliber, presence of necrotic fibers, autophagic voids of emissions filled with dense granules and membrane remnants, subsarcolemmal occurrences of mitochondria, and perivascular and endomysial inflammatory infiltrates.