Acute Coronary Syndrome Manifesting as an Adverse Effect of All-trans-Retinoic Acid in Acute Promyelocytic Leukemia: A Case Report with Review of the Literature and a Spotlight on Management

Table 1

Coagulation profile during the course of treatment.

	Day 1	Day 9	Day 10	Day 16	Day 25
Fibrinogen (180–350 mg/dL)	247 mg/dL	500 mg/dL	Patient had acute myocardial infarction	210 mg/dL	190 mg/dL
PT (INR)	Prolonged (no clot for >120 seconds)	Normal (1.4)		Normal (1.4)	Normal (1.2)
aPTT (control = 32 seconds)	Prolonged (>50 seconds)	Normal (29 seconds)		Normal (29.2 seconds)	Normal (29.2 seconds)
Platelet count (1,50,000–4,00,000/mm^3)	18,000/mm^3	56,000/mm^3		2,52,000/mm^3	4,96,000/mm^3
Interpretation	DIC	Thrombocytopenia, not in DIC		Normal	Normal
Total count (4,000–11,000/mm^3)	10,040/mm^3	10,400/mm^3		2,800/mm^3	3,900/mm^3