Pituitary Metastatic Composite Tumors: A Case Report with Next-Generation Sequencing and Review of the Literature

Figure 5

(a) Admixed pituitary adenoma (star) and the surrounding metastatic carcinoma (arrows) in one of the fragments. (b) Juxtaposition of pituitary adenoma (lower left) and metastatic renal cell carcinoma (upper right). (c) Pituitary adenoma shows sheets of cytologically bland, monotonous cells. (d) Renal cell carcinoma shows large atypical cells with prominent nucleoli and clear cytoplasms. (e) Synaptophysin is positive in the pituitary adenoma and negative in the renal cell carcinoma. PAX-8 shows nuclear positivity in the renal cell carcinoma, while the pituitary adenoma is negative. (a–e) Hematoxylin-eosin. (d, e) Immunohistochemistry. Original magnifications: (a) 20x; (b, e, f) 200x; and (c, d) 400x.

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