Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review

Figure 1

Morphologic features and immunophenotype of SCLC from supraclavicular lymph node biopsy obtained at the time of diagnosis in 2009. (a) H&E stain displaying the characteristic morphologic features of small-cell carcinoma including high nuclear to cytoplasm ratio, hyperchromatic nuclei with salt and pepper chromatin, inconspicuous nucleoli, and frequent mitoses. (b) AE1/AE3 stain demonstrating focal punctate or discontinuous staining that is usually observed in SCLC. (c, d) The neoplasm is diffusely positive for neuroendocrine markers synaptophysin and chromogranin. (e) TTF-1 expression is positive, suggesting pulmonary origin of tumor. (f) PD-L1 immunostain was negative in the initial biopsy and subsequent biopsied metastatic sites.

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