Case Report
Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?
Table 1
Data of case reports describing patients with CCCS and local recurrence or metastatic disease.
| Author | Patients () | Publication | Location of diagnosis | Type of resection | Local recurrence (; %) | Time of local recurrence | Metastatic disease (; %) | Location of metastasis | Time of metastasis (range) | Outcome |
| Unni et al. [2] | 16 | 1976 | N/A | 1 X N/A 8 X R0 7 X R1/2 | 4; 25% | 0.25 y–5 y (median 2 y) | 6; 38% | 5 X lung 2 X bones | 6 y–19 y (median 6.7 y) | 1 X N/A 10 X NED 1 X AWD 4 X DOD |
| Bjornsson et al. [7] | 47 | 1985 | N/A | 5 X N/A 23 X R0 19 X R1 | 16; 34% | 4.6 y | 7; 15% | 5 X lung 3 X bone | 3.5 y–7 y (median 4 y) | 9 X N/A 22 X NED 8 X AWD 8 X DOD |
| Komiya et al. [13] | 1 | 1986 | Femur | R2 | 0 | — | 1 | Bones/lung | 4 y | DOD |
| Lee et al. [14] | 1 | 1989 | Femur | R1 | 1 | 5.3 y | 0 | — | — | NED |
| Bagley et al. [12] | 2 | 1993 | N/A | R0 | 0 | — | — | 1; 50% | 23 y | 1 X NED 1 X AWD |
| Ron et al. [15] | 1 | 1995 | Rib | R0 | 1 | 0.4 y | 1 | Lung | 1 y | DOD |
| Ayoub et al. [16] | 6 | 1999 | Femur, ilium | 3 X R0 3 X R1/2 | 3; 50% | 2.8 y–19 y (mean 5 y) | 1; 17% | Lung | 5.5 y | 4 X NED 1 X AWD 1 X DOD |
| Hartwright et al. [17] | 1 | 2000 | Femur | R0 | 1 | 19 y | 0 | — | — | NED |
| Kalil et al. [4] | 3 | 2000 | Femur | 2 X R0 1 X R1 | 2; 67% | 0.6 y; 6 y | 3, 100% | 3 X lung 2 X bones | 1.2 y–6 y (median 5 y) | 3 X DOD |
| Itälä et al. [3] | 16 | 2005 | Femur, humerus, ulna, vertebra, rib, sternum | 10 X R0 6 X R1 | 3; 19% | 0.15–1.8 y (median 1.6 y) | 3, 16% | 1 X lung 2 X bones | 4 y–16.3 y (median 7 y) | 11 X NED 4 X AWD 1 X DOD |
| Kawano et al. [18] | 1 | 2005 | Left tibia | R0 | 0 | — | 1 | Bone | 4 y | NED |
| Srikanth et al. [19] | 1 | 2005 | Olecranon | R0 | 0 | — | 1 | Lung | N/A | DOD |
| Simsek et al. [20] | 1 | 2005 | Femur | R2 | 1 | 3 y | 0 | — | — | NED |
| Donati et al. [10] | 18 | 2008 | Femur, tibia, humerus, astragalus bone, vertebral body, scapula, rib, pubic ramus, acetabulum | 17 X R0 1 X R1 | 5; 28% | 0.5–24 y (median 4.6 y) | 2; 11% | Bone | 1 y–5.3 y (mean 3.1 y) | 15 NED 3 AWD |
| Elojeimy et al. [21] | 1 | 2013 | Humerus | R0 | 0 | — | 1 | Bone | 1 y | 1 X AWD |
| Jiang et al. [22] | 5 | 2014 | Femur, vertebra, rib, sacrum | 3 X R0 2 X R1 | 3; 60% | 1 y–8 y (median 2.5 y) | 3; 60% | Bone | 9.1–20 y (median 10 y) | 1 X NED 3 X AWD 1 X DOD |
| Laitinen et al. [11] | 1 | 2014 | Left proximal femur | R1 | 1 | 29 y | 100% | Lung | 29 y | AWD |
| Nagmani et al. [23] | 1 | 2015 | Calcaneum | R0 | 0 | — | 1 | Lung | 1.5 y | AWD |
| Moura et al. [24] | 1 | 2016 | Femur | R1 | 1 | 16 y | 0 | — | — | NED |
| Klein et al. (9) | 7 | 2019 | Proximal femur (5), proximal tibia (1), proximal humerus (1) | 7 X R0 | 2; 30% | 0.5 y | 1; 14% | Lung | 0.75 y | 6 X NED 1 X DOD |
| Caetano de Oliveira et al. [25] | 1 | 2021 | Left proximal femur | R1/2 | 1 | 0.25 y | 1 | Rib | 22 y | NED |
| Own case | 1 | | Right os naviculare | R1/2 | 1 | 0.3 y | 1 | Lung | 20 y | NED |
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NED: no evidence of disease; AWD: alive with disease; DOD: dead of disease.
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