A Rare Case of Large-Vessel Vasculitis following Checkpoint Inhibitor Therapy and Pegfilgrastim

Figure 1

(a) CT chest with contrast of the patient on 2/11/21. (b) CT chest with contrast of the patient on 5/03/21. (c) CT chest with contrast of the patient on 7/01/21. Between February and March 2021, this patient received both pembrolizumab and pegfilgrastim. Her May CT was significant for wall thickening and inflammatory changes surrounding the left subclavian artery extending into the aortic arch with involvement of the left carotid artery and proximal innominate arteries, new findings as compared to her February CT. After the initiation of a long steroid taper in May, the patient’s CT chest in July showed marked improvement of the wall thickening and inflammatory changes of the aortic arch and arch vessels, most compatible with resolving vasculitis.

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