Li-Fraumeni Syndrome With Six Primary Tumors—Case Report
Table 1
Patient’s timeline.
September 2005. Admitted for hospital treatment due to a large left breast tumor and underwent a tumorectomy.
October 2005. Admitted for a left-sided simplex mastectomy with a sentinel lymph node biopsy because the pathohistology report confirmed it was malignant tumor.
October 2007. Admitted for a secondary reconstruction of the left breast.
December 2007. Admitted due to palpitations and headaches, tested positive for pheochromocytoma, and underwent a right-sided adrenalectomy.
In 2009. Pregnancy carried out.
December 2014. Admitted to a hospital due to progressive ataxia and severe headaches. The MR confirmed a brain tumor, and the patient underwent craniotomy with the extirpation of the tumor mass.
In 2016/2017. Pregnancy. In the postpartum period, a palpable mobile mass was discovered and subsequently confirmed to be adrenocortical carcinoma.
In 2017. The patient gave birth and underwent a left-sided adrenalectomy, followed by lifetime substitution therapy with hydrocortisone.
May 2020. Admitted for a thymectomy.
May 2021. Admitted for a scheduled video-assisted thoracoscopic surgery to remove the lesions in the upper left lobe of the lung.
December 2021. Admitted for a radical right-sided subcutaneous mastectomy with a primary reconstruction of the breast with an endoprosthesis because of palpable lesions in the right breast.
February 2022. Admitted for a right lower lobectomy and atypical resection of the middle lobe of the lung due to adrenocortical carcinoma metastasis.
