Long Term Outcome and Histologic Findings of a Retinal Astrocytic Hamartoma Treated with Intravitreal Injection of Anti-VEGF: A Case Report

Figure 7

(a) Full montage of the enucleation specimen. (Left) The right eye showed complete serosanguinous retinal detachment, ectropion uveae, and anterior and posterior synechiae. The optic nerve head () is expanded and hypercellular with focal calcifications. In this image, the retrolaminar optic nerve appears normal () (hematoxylin and eosin stain). (Right) These areas are positive for glial fibrillary acidic protein (GFAP). (b) Astrocytic proliferation in the optic nerve head reminiscent of pilocytic astroctyoma. (Left panel) Areas of necrosis and prominent neovascularization are seen (10×). (Middle panel) Scattered calcifications throughout the lesional tissue (20×). Few eosinophilic granular bodies (arrows) are seen (40×). (Right panel) Immunohistochemistry for glial fibrillary acidic protein (GFAP) highlights the astrocytic proliferation (40×) (Left and middle panels: hematoxylin and eosin stain). (c) Astrocytic proliferation in the retrolaminar optic nerve reminiscent of subependymal giant cell astrocytoma. (Left panel) Large eosinophilic polygonal cells involving the optic nerve. There are focal calcifications (10×). (Middle panel) These large cells were located in between nerve fibers forming cords or distributed as single cells throughout the retrolaminar optic nerve. At higher magnification, the peripheral vacuolization and plump, granular, and eosinophilic cytoplasm of these cells is apparent. The nuclei and nucleoli are readily visible with some cells displaying irregular nuclear contours. (Right panel) Immunohistochemistry for glial fibrillary acidic protein (GFAP) is positive in these large epithelioid cells supporting a glial/astrocytic origin (20×) ((a)–(c): hematoxylin and eosin stain).

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