Challenges in the Management of Upper Lid Keloid

Figure 3

(a) Histopathology showing stretched out epithelium (green arrow), paucicellular thick collagen bundles, and few widely scattered blood vessels (red arrows) (hematoxylin-eosin stain-HE, 4x). Inset shows disorganised, large, hyalinised collagen fibres (HE, 20x). (b) TGF-β marker shows focal positivity (red arrowhead) in the interstitium suggesting active fibroblast activity (Immunohistochemistry, 40x). (c) Thick collagen bundles (black arrowhead) with a nodule of thick collagen fibres (black arrow) at the margin of the lesion (Masson-trichome stain, 10x).

(a)

(b)

(c)