Malignant Diffuse-Type Tenosynovial Giant Cell Tumor in the Subcutaneous Tissue of the Midthigh: A Report of a Rare Tumor in an Unusual Location

<div>The tumor grossly shows fleshy gray cut surface with well-circumscribed round edges (a). Histological examination shows nested pseudoalveolar proliferation of histiocytes and synoviocytes showing abundant eosinophilic cytoplasm with some perinuclear hemosiderin (H&amp;E, (b) -100x and (c) -200x). Scattered multinucleated osteoclast-like giant cells are seen (H&amp;E (c) -200x, arrow). The tumor shows atypical cytological features in the form of atypical mitotic figures (H&amp;E (d) -400x, arrow). The neoplastic cells are diffusely positive for immunohistochemical stain for clusterin antibody (clusterin IHC, (e) -upper right insert).</div>

Case Reports in Orthopedics

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Figure 2: Malignant Diffuse-Type Tenosynovial Giant Cell Tumor in the Subcutaneous Tissue of the Midthigh: A Report of a Rare Tumor in an Unusual Location 

Figure 2 | Malignant Diffuse-Type Tenosynovial Giant Cell Tumor in the Subcutaneous Tissue of the Midthigh: A Report of a Rare Tumor in an Unusual Location 