Middle Ear Neuroendocrine Adenoma: A Case Report and Literature Review

Figure 4

(a) Hematoxylin and eosin stain; the tumor was unencapsulated with an organoid growth pattern characterized by rounded nests and trabecular and glandular aggregates, with hyalinized fibrous stroma in the background (magnification ×25). Cytologically, the tumor cells lacked nuclear pleomorphism and exhibited finely dispersed nuclear chromatin (magnification ×100). (b) Immunohistochemistry results showed diffuse positivity for Cam 5.2.

(a)

(b)