Case Report

Combination Immunosuppressive Therapy in Primary Autoimmune Inner Ear Disease in Pregnancy

Table 5

Immunologic and cell markers, including flow cytometry profile and genetic studies.

Cell markers
CD19 pan B cell7%
CD20 mature B cell7%
Kappa light chain3%
Lambda light chain3%
CD3 T cells69%
CD4 helper subset34%
CD8 cytotoxic subset32%
Flow commentNo evidence of lymphoproliferative disease

Immunologic markers
Rheumatoid factor<10 IU/mL<15
Anti-CCP antibodies3 U/mL<5
IgG8.7 g/L6.6–15.6
IgA1.73 g/L0.75–3.80
IM1.56 g/L0.40–3.10
IgE19 U/mL<113
IgG13.76 g/L3.92–9.12
IgG22.60 g/L1.50–6.40
IgG30.48 g/L0.25–1.38
IgG40.27 g/L0.04–0.70
C1Q complement component155 mg/L118–244
C2 complement29.9 mg/L14.0–5.0
C3 complement1.30 g/L0.74–1.57
C4 complement0.28 g/L0.13–0.41
C5 complement>200.0 mg/L100–169
C6 complement120 mg/L45–96
C7 complement>110 mg/L55–85
C8 complement172.0 mg/L112–172
C9 complement500.0 mg/L125–265
Haptoglobin1.53 g/L0.30–2.15
A1 antitrypsin level2.38 g/L0.90–1.90
Serum total protein63 g/L46–70
Albumin EPG36 g/L37–51
Alpha1 globulin2.9 g/L0.9–2.0
Alpha2 globulin8.9 g/L2.8–7.7
Beta globulin8.9 g/L5.1–14.0
Gamma globulin6.9 g/L5.1–14.0
B2 microglobulin1.9 mg/L1.0–2.6
Glutamic acid decarboxylase antibody<5 U/mL≤5
Islet cell antigen 512 antibodies<8 U/mL0–15
Nuclear antibodiesDetected 1 : 640 speckled
dsDNA antibodiesPattern
RNP antibodies7 IU/mL0–29
SM (Smith) antigen antibodiesNot detected
SSA/Ro 60 antibodiesNot detected
Ro-52/TRIM 21 antibodiesNot detected
SSB/La antibodiesNot detected
Scleroderma 70 antibodiesNot detected
Jo-1 antibodiesNot detected
Neuronal antibodies: PurkinjeNot detected
(Yo), PCA 2, ANNA-1, ANNA-2, Ma 1, Ma 2, amphiphysin, CV2, Tr, and SOX-1Not detected
Smooth muscle antibodiesNot detected <1 : 40
Mitochondrial antibodiesNot detected <1 : 40
Parietal cell antibodiesNot detected <1 : 40
Intrinsic factor antibody4 U/mL<20
Thyroglobulin antibodies<20 IU/mL0–60
Thyroid peroxidase antibodies<10 IU/mL0–35
Heat shock protein 70 antibodiesDetected A
Pancreatic islet cell antibodiesNot detected
Gliadin IgG deamidated antibodies2 units<20
Transglutaminase IgA antibodies<1 U/mL<4
Neutrophil cytoplasm PR3 and MPO antibodiesNot detected
Ro-52, Mi-2, Ku, PM-Scl 100, PM-Scl 75, SRP, EJ, OJ, Jo-1, PL-7, and PL-12Negative
Zinc transporter 8 antibodiesNegative <10 U/mL

Genetic diagnostics
Thiopurine methyltransferase genotypeNo TMPT variant alleles
Factor V DNANo factor V Leiden mutation