Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature
Figure 2
Microscopic and immunohistochemical features of intrahepatic clear cell bile duct adenoma. (a) Hematoxylin-eosin stained low power view showing tumor composed almost exclusively of clear cells with entrapped bile ducts and surrounding liver parenchyma. (b) Stromal fibrosis and partial replacement of normal bile duct cells by clear cells. (c) The tumor cells have abundant clear cytoplasm and round to oval hyperchromatic nuclei with inconspicuous nucleoli. (d) The clear cells are focally positive for Alcian blue staining. (e–h) Immunohistochemical staining of clear cells demonstrates activity for CK7 (e) and polyclonal CEA (g) but negative staining for CK20 (f) and EMA (h). (g-h) Clear tumor cells demonstrated continuous apical staining for CD10 (g) and focal membraneous staining for CD56 (h) (a-b, ×100; c–h, ×400; i-j, ×200).
