Case Reports in Pathology / 2014 / Article / Tab 1 / Case Report
Cytopathologic, Histopathologic, and Immunohistochemical Features of Intrahepatic Clear Cell Bile Duct Adenoma: A Case Report and Review of the Literature Table 1 Clinicopathologic and immunohistochemical characteristics of reported cases of intrahepatic clear cell bile duct adenoma and clear cell cholangiocarcinoma.
Case number
Reference
Age (y)/ Size (cm)
Follow-up Immunohistochemistry CK7 CK20 EMA pCEA CD10 CD56 Ca 19-9 Vimentin Ki-67 p53 Intrahepatic clear cell bile duct adenoma 1 Albores-Saavedra 2 ] 50/M 0.8* Alive, 2 years + − + + (cytoplasmic) nd nd nd −
<10% in + (>50%) 2 Albores-Saavedra 2 ] 63/M 0.9 Alive, 2 months + − + + (cytoplasmic) nd nd nd − + (>50%) 3 Albores-Saavedra 2 ] 25/F 1.1 Alive, 18 years + − + + (cytoplasmic) nd nd nd − + (>50%) 4 Current case 37/F 2.8 Alive, 19 months + − − + + + (focal) + + (membrane) <2% + (>50%) Intrahepatic clear cell cholangiocarcinoma 1 Logani and Adsay (1998) [9 ] 64/F 12.0 nd nd nd nd nd nd nd nd − nd nd 2 Adamek et al. (1998) [10 ] 62/M 5.0 Died, 14 months + nd + nd nd nd nd nd nd nd 3 Tihan et al. (1998) [11 ] 72/M 15.0 Alive, 30 months + − + (focal) − nd nd nd − nd nd 4 Falta et al. (1999) [23 ] 50/M 1.5 Alive, 12 months + − + − nd nd nd + (focal) nd nd 5 Albores-Saavedra 2 ] 64/M 6.0 Alive, 3 years + (>50%) − nd + (>50%) nd nd nd nd >50% + (>50%) 6 Haas et al. (2007) [12 ] 51/M 9.0 Died, 3 years + − − − − + (20%) − + (20%) <5% nd 7 Haas et al. (2007) [12 ] 60/F 4.5 Alive, 1 year + (30%) − + (50%) − − + (10–20%) − − <2% nd 8 Haas et al. (2007) [12 ] 58/F 2.3 Alive + (10%) − − − − + (10–60%) − + (20%) 5% nd 9 Toriyama et al. 13 ] 56/M 2.2 Alive, 7 months + − + − − + (focal) + (focal) + 7.5% + (focal)
2 tumors, each measuring 0.8 cm; +: positive; −: negative; nd: no data.
