Metachronous Occurrence of Granular Cell Tumor in Breast Skin and Scalp: Diagnostic Challenging Differentiating Benign from Malignant and a Literature Review

Figure 2

(a) Subcutaneous mass on the vertex of the scalp with ulcerated surface. (b) Reactive pseudoepitheliomatous hyperplasia of epidermis (H&E, ×100). (c) Polygonal tumor cells forming nests (×200). (d) Tumor cells with large eosinophilic granular cytoplasm and oval nucleus with nucleoli (H&E, ×400). (e) Tumor cells showing approximately 6% Ki-67 proliferation index (×200). (f) Tumor cells expressing p53 weakly and mildly (×200). (g) Tumor cells expressing S100 protein diffusely and strongly. (h) Tumor cells immunohistochemically negative for cytokeratin AE1/AE3 (×200).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)