Leiomyosarcoma and Squamous Cell Carcinoma Arising in Mature Cystic Teratoma of the Ovary

Figure 1

Leiomyosarcoma in mature cystic teratoma of ovary. (a) The cyst lined by keratinized squamous epithelium. Note the intramural sarcomatous component beneath the cyst lining (H&E, 1.25x). (b) Leiomyosarcoma showed intersecting fascicles of malignant spindle cells (H&E, 10x). (c) Leiomyosarcoma exhibited moderate to markedly atypical spindle cells with blunt-ended (or cigar-shaped) nuclei and eosinophilic fibrillar cytoplasm. Note numerous mitotic figures (H&E, 40x). (d) Leiomyosarcoma showed strong and diffuse positivity for smooth muscle actin (IHC stain, 40x).

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