Paraneoplastic Pemphigus Involving the Respiratory and Gastrointestinal Mucosae

Figure 5

PNP-related gastrointestinal mucosal lesions: gastric antrum (a-c) and colon (d-f). Distorted pyloric glands and colonic crypts in the CMV-uninfected islands seen among extensively CMV-infected mucosae exhibit apoptotic cellular debris in the lumen (a and d: HE). Intraepithelial lymphocytes are increased in the colonic mucosa. As indicated by red arrows, IgG deposition is proven on the plasma membrane and in the cytoplasm of the involved epithelial cells (b and e: IgG immunostaining after proteinase-1 digestion). Cleaved caspase-3-immunoreactive apoptotic cells are clustered in the lumen of the diseased glands/crypts (c and f).

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