Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Clinicopathologic Analysis with Evaluation of the E-Cadherin/β-Catenin Complex and Associated Genetic Alterations

Figure 5

Case 3: (a) tumor cells and normal sebaceous glands retain positive staining for E-cadherin (inset: depicting complete membranous staining; 20x); (b) tumor cells and lacrimal gland acini show uniform, membranous β-catenin staining (10x); (c) high cytoplasmic/membranous staining for Src is identified in >50% of tumor cells (20x). Case 4: (d) strong E-cadherin expression is present (4x); (e) strong membranous and cytoplasmic staining for β-catenin (20x); (f) increased cytoplasmic expression of Src is noted in >50% of tumor cells (20x).

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