Case Reports in Pathology

Case Report

Epithelioid Malignant Peripheral Nerve Sheath Tumor in the Liver: Report of a Rare Unusual Case with Rhabdoid Morphology and Review of the Literature

Table 2

Immunophenotype of neoplasms in the differential diagnosis of epithelioid malignant peripheral nerve sheath tumor.


	Neoplasm
	EMPNST	Malignant rhabdoid tumor	Myoepithelial carcinoma	Epithelioid sarcoma	Malignant melanoma	MGNET

Immunostain
INI1	Absent (50-70%)	Absent (98%)	Absent (10-40%)	Absent (90%)	Retained	Retained
Keratin	Rare	Positive	Positive	Positive	Negative	Negative
EMA	Rare	Positive	Positive	Positive	Negative	Negative
SMA	Negative	Variable	Variable	Negative	Negative	Negative
Desmin	Negative	Variable	Negative	Negative	Negative	Negative
Myogenin	Negative	Negative	Negative	Negative	Negative	Negative
MelanA	Negative	Negative	Negative	Negative	Positive	Negative
HMB45	Negative	Negative	Negative	Negative	Positive	Negative
SOX10	Positive	Negative	Positive	Negative	Positive	Positive
S100	Positive	Variable	Positive	Negative	Positive	Positive
GFAP	Negative	Variable	Negative	Negative	Negative	Negative
CD34	Negative	Negative	Negative	Variable	Negative	Negative

EMPNST with rhabdoid differentiation may express SMA. ^Please note that the immunophenotypes for the neoplasms listed above may deviate from what is listed. Abbreviations: EMPNST: epithelioid malignant peripheral nerve sheath tumor; MGNET: malignant gastrointestinal neuroectodermal tumor; EMA: epithelial membrane antigen; SMA: smooth muscle actin; GFAP: glial fibrillary acidic protein.