A Rare Case of Multifocal Asynchronous Benign Granular Cell Tumors with <i>PIK3CA</i> Subclonal Mutation Identified in One Tumor by Next-Generation Sequencing

<div><i>PIK3CA</i> p.H1047R. Alignment in IGV_2.12.0 (integrative genomics viewer, <a href="https://software.broadinstitute.org/software/igv">https://software.broadinstitute.org/software/igv</a>) shows a substitution c.3140A&gt;G with 124 reads of G (orange) and 1640 reads of A (green), schematically shown in the column diagram of the coverage track. This changes the triplet code CAT for Histidine (H in the amino acid reference sequence) to CGT for Arginine in codon 1047 in exon 21 of the <i>PIK3CA</i> oncogene (reference sequence: NM_006218.4).</div>

Case Reports in Pathology

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Figure 2: A Rare Case of Multifocal Asynchronous Benign Granular Cell Tumors with <i>PIK3CA</i> Subclonal Mutation Identified in One Tumor by Next-Generation Sequencing 

Figure 2 | A Rare Case of Multifocal Asynchronous Benign Granular Cell Tumors with PIK3CA Subclonal Mutation Identified in One Tumor by Next-Generation Sequencing 