A PAX-8-Positive Female Urethral Adenocarcinoma, Intestinal-Type: A Case Report with Diagnostic Challenges and a Review of the Literature

Figure 2

(a) Histologic sections of the needle core biopsy of a right lower lobe nodule demonstrated a proliferation of neoplastic glands with pseudostratified columnar epithelium and intraluminal mucin secretions, consistent with moderately differentiated adenocarcinoma. Immunohistochemistry revealed positivity for cytokeratin 7 (CK7) (b), cytokeratin 20 (CK20) (c), and PAX-8 (d). Transcription termination factor-1 (TTF-1) (e) and estrogen receptor (ER) (f) were negative. Magnifications in (a)–(c) and (f) is 10x and in (d) and (e) is 20x.

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