A PAX-8-Positive Female Urethral Adenocarcinoma, Intestinal-Type: A Case Report with Diagnostic Challenges and a Review of the Literature

Figure 4

(a) Histologic sections of the urethral biopsy showed intestinal metaplasia of squamous mucosa with transition from a mature to dysplastic phenotype with the adenocarcinoma appearing to originate from the dysplastic intestinal metaplasia. Immunohistochemistry showed positivity for CK20 (b), caudal-type homeobox 2 (CDX2) (c), patchy expression of SAT-B2 (d) and PAX-8 (e), and negative for p16 (f). Magnification in (a), (b), and (f) is 10x and in (c)–(e) is 20x.

(a)

(b)

(c)

(d)

(e)

(f)