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| Source | Subjects | Disease | Signs and symptoms | Treatment | Efficacy of treatment |
|
| Hart et al. [4] | Male with cherubism diagnosed when he was 6 years old | Cherubism | Pain localized in mandible | Calcitonin and bisphosphonates | Pain reduction |
|
| Zumkeller et al. [5] | Male child 8 years old | McCune-Albright syndrome and pituitary adenoma | Polyostotic dysplasia, Cafè-au-lait spots, and precocious puberty | Pamidronate and sandostatin | Increased mobility |
|
| Rastogi et al. [6] | 15-year-old female | McCune-Albright syndrome | Recurrent fractures of femur by minor trauma and chronic bone pain (right thigh) | Pamidronate i.v. (1 mg/kg/day for 3 days once in 3 months for a period of 1 year), 25-hydroxy-vitamin D, and calcium | Pain reduction and no fractures developed over three years of follow-up |
|
| Kochar and Kulkarni [7] | 2- and 8-year-old female | McCune-Albright syndrome | Generalized bone pain, recurrent fractures by minor trauma, fatigue, and bone deformities | Pamidronate i.v. | Remarkable clinical improvement |
|
| Atsali et al. [8] | 14-year-old female | McCune-Albright syndrome | Cystic lesions of the right humerus incidentally discovered, bone pain, and a history of fracture of the distal humerus by minor trauma | At first, pamidronate i.v. and then i.v. zoledronic acid (5 mg annually) | During treatment, pain reduction, no fractures, and increased BMD after 4 years of therapy |
|
| Bieniasz et al. [9] | 12-year-old female | Craniofacial FD | Orbital cavity and sinuses lesions | Pamidronate | Clinical improvement |
|
| Mäkitie et al. [22] | 12-year-old female | Craniofacial FD | Mandibular lesions, swelling, disfigurement, and pain of the right side of the jaw | Pamidronate i.v. (1 mg/kg on 3 consecutive days at 4-month intervals), in the following year, the therapy was switched to zoledronic acid i.v. (0.05 mg/kg once every 6 months) | Pain and disfigurement reduction |
|
| Khadilkar et al. [11] | 3-year-old male | Polyostotic FD | Recurrent fractures of the left femur, pain, and asymmetry | Oral alendronate | Pain reduction and no fractures |
|
| Chattopadhyay et al. [12] | 17-year-old female | Polyostotic FD and hypophosphatemia | Swelling of the left forearm, progressive bowing deformity of the lower limb, widening of the wrist, decrease in linear growth with sever short stature, rickets, and osteomalacia | Oral alendronate, phosphate, and 25-hydroxy-vitamin D | Clinical improvement |
|
| Jayaraman et al. [13] | 18-year-old female | Polyostotic FD | Pain, swelling and fracture in the right middle finger after minor trauma, and expansive lesions in the right hand and in the superior pubic ramus | Oral alendronate (70 mg weekly), calcium carbonate 1000 mg daily, and 25-hydroxy-vitamin D 400 IU daily | Radiographic improvement of bone lesions |
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