Mitochondrial Disease as a Cause of Neonatal Hemophagocytic Lymphohistiocytosis

Figure 1

(a) Clinical course which is related to liver dysfunction. This figure shows the laboratory findings that are related to liver function. In a few days after birth, severe liver failure with a dominant increase in unconjugated bilirubin was evident. After that, aspartate aminotransferase and alanine aminotransferase levels were decreased; on the other hand, conjugated bilirubin level was increased. (b) Clinical course while she was hospitalized. This figure shows the clinical course of the patient. Thrombocytopenia did not improve after continuous platelet transfusion. Administration of vitamin B1, vitamin B2, vitamin C, Carnitine, and Coenzyme Q10 is a supporting therapy for mitochondrial disease. FFP: fresh frozen plasma. RCC-LR: red cell concentrates-leukocyte reduced.

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