Atrioventricular Conduction Abnormalities in Multisystem Inflammatory Syndrome in Children

Table 1

Clinical features of 3 patients with multisystem inflammatory syndrome in children.

Clinical feature	Patient #1	Patient #2	Patient #3
Age/weight (kg)	19 (71 kg)	9 (31 kg)	9 (45.8 kg)
Sex	M	M	M
Race/ethnicity	Hispanic	Black, Hispanic	Black
Preexisting conditions	n/a	n/a	Obese and recent appendectomy
Acuity	PICU^€	PICU^€	CVICU^¥
Co-infection	None	None	N/a
Known sources/sick contacts	None	None	Brother had complaints of abdominal pain
Abdominal pain/emesis	+	+	+
Respiratory failure	+	+	−
Shock	+	+	+
Erythematous lips	−	+	+
Headaches	−	+	−
Conjunctivitis	−	−	+
Cardiopulmonary support
Ventilation support	HFNC^β	MV^Δ	None
Vasoactive support	Epi^ç, Iso^£	Epi, Mil^Ş	None
Fluid first 24 hours	100 ml/kg	110 ml/kg	67 mL/kg
Anti-inflammatory therapies
Intravenous immunoglobulin (2 g/kg)	100 g × 2 (2,000 mL)	68.2 g × 1 (682 mL)	85 g × 1 (850 mL)
Methylprednisolone	+	+	+
Other anti-inflammatory meds	Anakinra, tocilizumab	Anakinra	Anakinra
Antibiotics	Azithromycin, vancomycin, ceftriaxone, piperacillin-tazobactam	Vancomycin, ceftriaxone	Ceftriaxone
Initial chest radiograph findings	Right lung base opacities	Multifocal infiltrates	Normal

^€Pediatric Intensive Care Unit. ^£Isoproterenol. ^¥Cardiovascular Intensive Care Unit. ^ŞMilrinone. ^βHigh-flow nasal cannula. ^çEpinephrine. ^ΔMechanical ventilation.