Case Series
Continuous Renal Replacement Therapy (CRRT) for Nonrenal Indications among Critically Ill Children with Malignancy
Table 1
Clinical characteristics and continuous renal replacement therapy (CRRT) parameters of the three patients.
| | Variable | Patient 1 | Patient 2 | Patient 3 |
| | Clinical characteristics | | Age (year) | 17.1 | 15.4 | 8.5 | | Sex | Female | Male | Male | | Indication for CRRT | Lactic acidosis | Sepsis/cytokine storm | Hyperbilirubinaemia | | Pre-CRRT fluid overload (%) | −1.6% (over 12 hours) | +1.4% (over 24 hours) | −2.6% (over 24 hours) | | Pre-CRRT urine output (ml/kg/hour) | 3.8 (over 12 hours) | 3.7 (over 24 hours) | 0.04 (over 24 hours) | | PIM3 predicted mortality (%) | 6.2 | 24.2 | 5.9 | | Pre-CRRT creatinine (μmol/L) | 29 | 45 | 55 | | Pre-CRRT eGFR (ml/min/1.73 m2) | 210.2 | 133.8 | 45.6 | | Need for mechanical ventilation | No | Yes | No | | Need for inotropes | No | Yes | No |
| | CRRT parameters | | Technique | High-volume hemodiafiltration | Hemoperfusion | Single-pass albumin dialysis | | Time to therapy (hour) | 11.9 | 48 | 203.8 | | Filter | ST100 | Oxiris® | ST100 | | Mean blood flow rate (ml/kg/min) | 4.7 | 4.1 | 3.7 | | Mean replacement rate (ml/kg/hour) | 21.4 | 32.5 | 23.0 | | Mean dialysate rate (ml/kg/hour) | 72.7 | 32.2 | 30.3 | | Mean dose (ml/kg/hour) | 94.8 | 56.6 | 59.2 | | Maximal dose (ml/kg/hour) | 111.1 | 73.2 | 60.0 | | Anticoagulation | Heparin | Nil | Nil | | Treatment duration (hour) | 160.9 | 37.0 | 42.1 |
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Dose = replacement rate + dialysate rate; eGFR: estimated glomerular filtration rate; PIM3: Pediatric Index of Mortality 3. |
