Infection-Induced Elevated Plasma Perampanel in a Patient with Hemimegalencephaly

Table 1

Case reports of impaired consciousness due to perampanel.

Case	Age (years)	Sex	Dose	Underlying disease	Trigger	Period of impaired consciousness (days)	Outcome
Li et al., 2018 [5]	54	Male	300 mg (once)	Refractory epilepsy	Overdose	4	He had cerebellar symptoms after awakening, but recovered spontaneously.
Wu et al., 2019 [4]	40	Male	60 mg (once)	Depression; History of overdose	Overdose	1	He self-extubated after mechanical ventilation was administered.
							He was aggressive after waking and was sedated for 5 days.
							He had irritability and anxiety until the 9th day.
Hoppner et al., 2013 [6]	34	Female	204 mg (once)	Partial epilepsy; Tuberous sclerosis	Overdose	2	She was disorientated after awakening, but recovered spontaneously.
Mutata and Nobukuni, 2020 [7]	74	Female	6 mg (every day)	Temporal epilepsy	Infection	Not provided	She was treated with an antimicrobial infusion and her consciousness gradually improved.
Our patient	15	Male	10 mg (every day)	Hemimegalencephaly; Refractory epilepsy	Infection	8	He recovered after IVIG and tapering off perampanel treatment.

IVIG, intravenous immunoglobulin.