Infection-Induced Elevated Plasma Perampanel in a Patient with Hemimegalencephaly

Table 2

Evaluation of the causal relationship between perampanel and impaired consciousness using the Naranjo scale.

	Yes	No	Do not know	Score
1. Are there previous conclusive reports on this reaction?	+1	0	0	+1
2. Did the adverse event appear after the suspected drug was administered?	+2	−1	0	+2
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	+1	0	0	+1
4. Did the adverse reaction reappear when the drug was readministered?	+2	−1	0	0
5. Are there alternative causes (other than the drug) that could on their own have caused the reaction?	−1	+2	0	+2
6. Did the reaction reappear when a placebo was given?	−1	+1	0	0
7. Was the drug detected in blood (or other fluids) in concentration known to be toxic?	+1	0	0	+1
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+1	0	0	0
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1	0	0	0
10. Was the adverse event confirmed by any objective evidence?	+1	0	0	0
			Total score	+7

Total score ≥9, definite ADR; 5–8, probable ADR; 1–4, possible ADR; 0, doubtful ADR. ADR, adverse drug reaction.