Growth Hormone Therapy for Small for Gestational Age Short Stature Develops Type 2 Diabetes

Table 1

Changes in blood hemoglobin A1c, insulin-like growth factor-1, and hormone levels during treatment with growth hormone.

Age (y/m)	9/6	10/0	10/6	11/0	11/4
HbA1c (%)	5.5	5.8	5.8	7.4	8.5
IGF-1 (ng/mL)	376	366	559	693	542
[M ± SD] [5]	[264 + 0.6 SD]	[302 + 0.2 SD]	[302 + 1.4 SD]	[333 + 1.7 SD]	[333 + 1.0 SD]
LH (mIU/mL)	0.11	0.26	3.45	4.37	4.8
FSH (mIU/mL)	2.39	3.99	4.62	5.57	5.97
Estradiol (pg/mL)	<10	13	15	36	65

HbA1c: glycosylated hemoglobin, IGF-1: insulin-like growth factor-1, M ± SD: median ± standard deviation, LH: luteinizing hormone, FSH: follicle-stimulating hormone, and y/m: years and months of age.