Case Report
Ciprofloxacin and Clozapine: A Potentially Fatal but Underappreciated Interaction
Table 2
US July 2013 CLOZARIL package insert table on dose adjustment in patients taking concomitant strong CYP 1A2 inhibitors.
| Comedications | Scenarios |
| | Initiating CLOZARIL while taking a comedication | Adding a comedication while taking CLOZARIL | Discontinuing a comedication while continuing CLOZARIL | Strong CYP1A2 inhibitors | Use one third of the CLOZARIL dose | Increase CLOZARIL dose based on clinical response |
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