Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report

Table 1

Main antibodies against intracellular antigens associated with autoimmune encephalitis.

Antibody	Associated syndrome	Tumor frequency	Tumor type
Anti-Hu	Limbic encephalitis, encephalomyelitis, sensory neuropathy, cerebellar degeneration, autonomic neuropathy [10]	>90%	Small-cell lung cancer, neuroblastoma, prostate cancer
Anti-RI	Romboencephalitis, myoclonus opsoclonus, cerebellar degeneration [10]	>90%	Small-cell lung cancer, gynaecological tumors, breast cancer
Anti-Ma	Limbic encephalitis, rhomboencephalitis, cerebellar degeneration [32]	>90%	Testicular tumors, small-cell lung cancer, breast cancer
Antiamphiphysin	Stiff-man syndrome, Lamber Eaton syndrome, motor-sensory polyneuropath, encephalomyelitis, paraneoplastic cerebellar degeneration. [33]	>90%	Breast, small-cell lung cancer
Anti-CV2/CRMP5	Limbic encephalitis, encephalomyelitis, optic neuritis, cerebellar degeneration, sensory-motor neuropathy, chorea [34]	>90%	Small-cell lung cancer, thymoma
Anti-GAD65	Limbic encephalitis: prodominant temporal lobe epilepsy with moderate cognitive impairment. It is also associated with stiff person [35].	Not associated	Associated with other autoimmune diseases such as diabetes and thyroiditis
GFAP-IgG	Autoimmune meningoencephalomyelitis,; Autoimmune astrocytopathy [36]	20%	Teratoma, adenocarcinoma

CRMP5: collapsin response mediator protein; 5 GAD: glutamic acid decarboxylase; GFAP-IgG: glial fibrillary acidic protein immunoglobulin G.