Managing Bipolar Disease Complicated with Psychosis in Conjunction with Polypharmacy, Parkinson’s Disease, and Multiple Comorbidities

Table 1

[17] First- and second-generation antipsychotics and D2 antagonism.

Antagonistic D2 effect	First-generation antipsychotics	Second-generation antipsychotics
Low	Chlorpromazine; Levomepromazine; Thioridazine	Clozapine; Quetiapine
Intermediate	Trifluoperazine; Perphenazine	Olanzapine
High	Haloperidol; Fluphenazine; Flupentixol	Risperidone; Ziprasidone; Aripiprazole (possible D2 agonism)

Table 1 is reproduced from Divac et al. 2015 [under the Creative Commons [Attribution License/public domain]].