Goodpasture’s Syndrome and p-ANCA Associated Vasculitis in a Patient of Silicosiderosis: An Unusual Association

Figure 2

Photomicrograph showing (a) voluminous, heavy, and subcrepitant lungs which on cut surface showed haemorrhagic consolidation, (b) dominantly fresh alveolar hemorrhages (H&E, ×200), (c) linear IgG deposits on alveolar lining and capillary basement membrane by immunofluorescence, (d) pleura with numerous 0.2-0.3 cm white nodules scattered throughout the surface, (e) interstitial nodules well demarcated from adjacent lung parenchyma characterized by concentrically arranged fibroblasts and hyalinized lamellated arrangement of the collagen bundles (inset showing small polarizable refractile oval to needle shaped particles within the nodules) (H&E, ×100), (f) Perl’s stain highlighting the iron content in dust macules in peribronchiolar and perivascular location composed of macrophages containing brown black particles (Perl’s stain, ×200).

(a)

(b)

(c)

(d)

(e)

(f)