A Rare Case of Metastatic Choriocarcinoma of Lung Origin

Figure 4

RUL mass biopsy. (a) Touch imprint cytology from core needle biopsy demonstrates bizarre, pleomorphic cells arranged in a dissociative fashion. Some of the tumor cells are multilobulated to multinucleated with pleomorphic, hyperchromatic nuclei (Diff-Quik stain ×20). (b) Core needle biopsy reveals bizarre syncytiotrophoblasts characterized by pleomorphic cells, including some that are multilobulated to multinucleated. The cells have a moderate amount of surrounding eosinophilic cytoplasm. Extensive necrosis is noted in the cores (H&E ×20). (c) Immunohistochemical stain for beta-hCG shows intense strong positive cytoplasmic staining (×40). (d) Strong diffuse positive cytoplasmic and membranous staining for PLAP (×40).

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