Case Report

A Case of Granulomatosis with Polyangiitis with Various Breast Lesions as the Initial Symptoms: A Case-Based Review

Table 1

Clinical characteristics of 35 cases of breast lesions with GPA.

Mean age ± SD years49 ± 14 (28–81)

GenderMale: 2, female: 33

ANCAPR3(C)-ANCA: 10
Negative: 4
Not described: 21

Location of breast lesionBilateral: 7
Unilateral: 28 (right: 18, left: 9, unknown: 1)

Formation of breast lesionNodule/tumor: 31
Ulceration: 6
Discharge from nipples: 1

Onset of breast lesionInitial symptom: 19
Onset after GPA diagnosis: 15

Pathology of breast lesionNecrotizing granulomatous vasculitis: 25
Granulomatous mastitis: 4
Others (inflammation with giant cells, panniculitis): 5

TreatmentCorticosteroid: 28
Cyclophosphamide: 16
Rituximab: 4