Autoinflammatory/Autoimmunity Syndrome Induced By Adjuvants (ASIA) Due to Silicone Incompatibility Syndrome

Table 2

Diagnostic criteria for ASIA syndrome.

Major criteria	Minor criteria
Exposure to an external stimulus (adjuvants) before clinical manifestations	The appearance of autoantibodies or antibodies directed to the suspected adjuvant
Appearance of “typical” clinical manifestations; (i) Myalgia, myositis, or muscle fatigue; (ii) Arthralgia and/or arthritis; (iii) Chronic fatigue and sleep disturbance; (iv) Neurological manifestations associated with demyelination; (v) Cognitive decline and memory loss; (vi) Pyrexia and dry mouth; (vii) Improvement of symptoms after extraction of the inducing agent; (viii) Positive biopsy of affected tissues	Other clinical manifestations (irritable colon syndrome); Presence of HLA (HLA DRB1 and HLA DQB1); Evolution of an autoimmune disease (multiple sclerosis and systemic sclerosis)