A Case of SAPHO Syndrome Complicated by Uveitis with Good Response to Both TNF Inhibitor and JAKinib

Table 1

Differential diagnoses of SAPHO syndrome in adults and children (infectious and malignancy excluded).

	Commonality	Difference
In adults
Psoriatic arthritis	Axial, appendicular arthritis, and psoriasis	Dactylitis, nail changes, no acne, no osteomyelitis
Paget disease	Osteitis	Old age predominance, both lytic and sclerotic changes, no cutaneous involvement
Tietze disease	Clavicular involvement is seen	Lack of arthritis, cutaneous features
Sweet syndrome	Neutrophilic dermatosis and aching joint are presentations	Lack of axial and appendicular arthritis, no acne
In children only
Majeed syndrome	Multifocal osteomyelitis	Congenital dyserythropoietic anaemia is typical of Majeed, transient skin changes, caused by recessively inherited mutations in LPIN2
DIRA(deficiency of Il-1 receptor antagonist)	Generalised pustulosis, osteitis, periostitis, and systemic inflammation	Recessively inherited mutation due to IL1-RN
Ewing sarcoma	Bony involvement	No skin changes
Histiocytosis	Bone and skin involvement	Clinical and pathological findings differ