Case Report

Antisynthetase Syndrome in a Patient with Pulmonary Embolism and Nonbacterial Thrombotic Endocarditis

Table 1

Diagnostic criteria for antisynthetase syndrome.

Connors et al. [4]Solomon et al. [5]

Required: presence of an antiaminoacyl tRNA synthetase antibodyRequired: presence of an antiaminoacyl tRNA synthetase antibody

PLUS one or more of the following clinical features:PLUS two major or one major and two minor criteria:
(i) Raynaud’s phenomenonMajor
(ii) Arthritis(i) Interstitial lung disease (not attributable to another cause)
(iii) Interstitial lung disease(ii) Polymyositis or dermatomyositis
(iv) Fever (not attributable to another cause)Minor
(v) Mechanic’s hands (hyperkeratosis with thickened and cracked skin on hands)(i) Arthritis
(ii) Raynaud’s phenomenon
(iii) Mechanic’s hands